α5 β1 -integrins are sensors for tauroursodeoxycholic acid in hepatocytes

β1 integrin is a long-sought sensor for tauroursodeoxycholic acid.

Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways.

Ursodeoxycholic acid (UDCA) is used in the treatment of cholestatic liver diseases, but its mechanism of action is not yet well defined. The aim of this study was to explore the protective mechanisms of the taurine-conjugate of UDCA (tauroursodeoxycholic acid [TUDCA]) against glycochenodeoxycholic acid (GCDCA)-induced apoptosis in primary cultures of rat hepatocytes. Hepatocytes were exposed to...

β1-integrins and glomerular injury

The renal glomerulus is composed of three types of glomerular cells (mesangial cell (MC), endothelial cell and podocyte) and extracellular matrix (ECM) consisting of the glomerular basement membrane (GBM) and mesangial matrix. It constitutes ahighly specialized microcirculation in which the permeability characteristics of the capillary wall allow its unique filtrationfunction.Theproliferationof...

β1 Integrins Are Critically Involved in Neutrophil Locomotion in Extravascular Tissue In Vivo

Recruitment of leukocytes from blood to tissue in inflammation requires the function of specific cell surface adhesion molecules. The objective of this study was to identify adhesion molecules that are involved in polymorphonuclear leukocyte (PMN) locomotion in extravascular tissue in vivo. Extravasation and interstitial tissue migration of PMNs was induced in the rat mesentery by chemotactic s...

Neural precursor cell chain migration and division are regulated through different β1 integrins

Thomas S. Jacques1, João B. Relvas1, Stephen Nishimura2, Robert Pytela4, Gwynneth M. Edwards3, Charles H. Streuli3 and Charles ffrench-Constant1,5,* 1Wellcome/CRC Institute of Developmental Biology and Cancer, Tennis Court Road, Cambridge, CB2 1QR and Department of Medical Genetics, University of Cambridge, Cambridge, UK 2Department of Anatomic Pathology, University of California San Francisco,...